�One of the world's longest and largest trials of hormone replacement therapy (HRT) has found that post-menopausal women on HRT gain significant improvements in quality of life.
The results of the latest study by the WISDOM enquiry team (Women's International Study of long Duration Oestrogen after Menopause) are published today on the British Medical Journal website http://www.bmj.com.
The study mired 2130 postmenopausal women in the UK, Australia and New Zealand, and assessed the impact of combined oestrogen and progestogen endocrine therapy on the women's quality of life. The average long time of women in this study was 13 geezerhood after change of life and most participants did not have menopausal symptoms.
"Our results show that live flushes, nighttime sweats, wakefulness and joint pains were less mutual in women on HRT in this age group. Sexuality was also improved," says Professor Alastair MacLennan, leader of the Australian arm of WISDOM and head of Obstetrics & Gynaecology at the University of Adelaide, Australia.
"Overall, quality of life measures improved. Even when women did not have hot flushes and were well past times menopause, in that respect was a small only measurable betterment in quality of life and a noted improvement in eternal sleep, sexuality and joint nisus. HRT users also had more titty tenderness and discharge compared to those on a placebo," he says.
Dr Beverley Lawton, Head of WISDOM New Zealand, says: "These new data should be added to the risk/benefit equation for HRT. The quality of life benefits of HRT may be greater in women with more serious symptoms near menopause. New research suggests that HRT taken from near change of life avoids the cardiovascular risks seen when HRT is initiated many years later menopause."
Professor MacLennan says studies such as those conducted by WISDOM "enable the risks of HRT to be rock-bottom and its benefits maximized when the treatment is individualized to each woman".
"Early start-up side effects privy usually be alleviated by adjusting the treatment," he says. "For most women with pregnant menopause symptoms the benefits of HRT outweigh the risks. The latest analyses of the main long-run randomized control trial of HRT (The Women's Health Initiative) demonstrate that tit cancer is not increased by oestrogen-only HRT and is only increased in women using combined oestrogen and progestin HRT subsequently seven years of use. This increased risk is less than 0.1% per year of use.
"If a woman feels that HRT is needed for quality of life, so doctors can buoy find the safest regimen for her. She tin can try release off HRT every 45 years, and can then make an informed alternative about whether she takes and continues HRT."
The WISDOM research is independent of the pharmaceutical industry and has been funded by UK, Australian and New Zealand government research bodies.
University of Adelaide
Level 1, 115 Grenfell St.
Adelaide 5005
Australia
http://www.adelaide.edu
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